DOP19 Spermidine treatment ameliorates experimental colitis in vivo

Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat.

The effect of electroacupuncture (EA) on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4% acetic acid. EA (2 Hz, 0.05 ms, 2 V for 20 min) was applied to bilateral Hoku (LI-4) and Zusanli (ST-36) on 12 hrs and 36 hrs after induction of colitis. EA-treatment significantly reduced the macroscopic damage and the myeloperoxidase act...

Mice Ameliorates Experimental Colitis in Intestinal Nematode Infection

Intestinal nematode infection ameliorates experimental colitis in mice.

Epidemiological studies suggest that inflammatory bowel disease (IBD) is common in developed countries and rare in countries where intestinal nematode infections are common. T cells are critical in many immune responses, including those associated with IBD and nematode infection. Among the distinct T helper (Th) cell subsets, Th1-type immune response is predominantly associated with Crohn's dis...

Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis.

Recent studies indicate that the CXCL12/CXCR4 interaction is involved in several inflammatory conditions. However, it is unclear whether this interaction has a role in the pathophysiology of inflammatory bowel disease (IBD). We investigated the significance of this interaction in patients with IBD and in mice with dextran sulfate sodium (DSS)-induced colitis and the effect of a CXCR4 antagonist...

EXPERIMENTAL COLITIS Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice Mamdouh A K Sedhom, Mélanie Pichery, Jenna R Murdoch, Benoit Foligné, Nathalie Ortega, Sylvain Normand, Kirsten Mertz, Devika Sanmugalingam, Lea Brault, Teddy Grandjean, Emma Lefrancais, Padraic G Fallon, Valérie Quesniaux, Laurent Peyrin-Biroulet, Gieri Cathomas, Tob...